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| CAPA 6-12 | B | 1 | Southwest Region at PennWest California | Pittsburgh Public Schools | PA | |
| Franklin Regional Middle School | B | 2 | Southwest Region at Penn West University | Franklin Regional | PA |
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| Harlan Rowe Middle School | B | 2 | Northeast Region at PSU Wilkes-Barre | Athens Area School District | PA |
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| Hudson Middle School | B | 3 | Akron Regional Science Olympiad (Eastern) | Hudson City Schools | OH |
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| Kenston Middle School | B | 1 | Northeast & Northern Ohio Regional Tournament | Kenston Local Schools | OH |
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| North Clarion High School | B | 1 | Northwest Region at PennWest Clarion | North Clarion County | PA | |
| North Pocono Middle School | B | 3 | Northeast Region at PSU Wilkes-Barre | North Pocono School District | PA | |
| Quaker Valley Middle School | B | 1 | Southwest Region at PennWest California | Quaker Valley School District | PA | |
| Springhouse Middle School | B | 2 | Central East Region at Kutztown University | Parkland | PA |
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| Tower Heights Middle School | B | 2 | Western Ohio Regional Tournament | Centerville City Schools | OH | |
| Winchester Thurston Middle School | B | 2 | Southwest Region at Penn West University | Winchester Thurston | PA | |